中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (4): 711-712.doi: 10.4103/1673-5374.382240

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

药物暴露史的表观遗传记忆控制成人脑神经干细胞的静止

  

  • 出版日期:2024-04-15 发布日期:2023-09-15

Epigenetic memory of drug exposure history controls neural stem cell quiescence in the adult brain

Masakazu Iwamoto, Taito Matsuda*   

  1. Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • Online:2024-04-15 Published:2023-09-15
  • Contact: Taito Matsuda, PhD, matsuda.taito.344@m.kyushu-u.ac.jp.
  • Supported by:
    This work was supported by a Grant-in-Aid for Scientific Research (B) JP21H02808 (to TM) and JST SPRING JPMJSP2136 (to MI).

摘要: https://orcid.org/0000-0002-9859-5967 (Taito Matsuda)

Abstract: Neural stem cells (NSCs) are the source of all neurons and glial cells (astrocytes and oligodendrocytes) in the central nervous system. The adult mammalian brain retains NSCs in the subgranular zone of the dentate gyrus in the hippocampus and ventricular subventricular zone lining the lateral ventricle (Olpe and Jessberger, 2022). Adult NSCs in rodents are preserved throughout life and continuously produce new neurons that integrate into the pre-existing neuronal network. However, whether adult neurogenesis occurs in humans, especially in the hippocampus, remains yet to be proven (Olpe and Jessberger, 2022). Adult neurogenesis in the hippocampus contributes to hippocampus-dependent cognitive function (Gonçalves et al., 2016). Disruption of this neurogenesis is known to be associated with several brain disorders, such as age-dependent cognitive decline, major depressive disorders, and medial-temporal lobe epilepsy. Thus, elucidating the mechanisms underlying the regulation of NSC behavior and neurogenesis is important for developing therapeutic strategies to treat diseases related to impaired adult neurogenesis.