中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (4): 723-724.doi: 10.4103/1673-5374.382251

• 观点:退行性病与再生 • 上一篇    下一篇

神经退行性疾病中胶质细胞向神经元转化的原位转化疗法目前存在的争议

  

  • 出版日期:2024-04-15 发布日期:2023-09-15

Current controversies in glia-to-neuron conversion therapy in neurodegenerative diseases

Peng Cao*, Jianan Li, Zhuxi Liu, Guobiao Liang#br#   

  1. Department of Neurosurgery, General Hospital of the Northern Theater Command of Chinese People’s Liberation Army, Shenyang, Liaoning Province, China (Cao P, Li J, Liang G)
    Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China (Liu Z)
  • Online:2024-04-15 Published:2023-09-15
  • Contact: Peng Cao, MD, pengcao518@163.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81971133; Liaoning Key Research and Development Project, No. 2021JH2/10300059; Liaoning Revitalization Talents Prograrn, No. XLYC2002109 (all to GL).

摘要: https://orcid.org/0000-0002-2809-506X (Peng Cao)

Abstract: Loss of neurons and disruption of neural circuits are associated with many neurological diseases, including neurodegenerative diseases and mental disorders. The most prevalent pathological feature of neurodegenerative diseases is the aggregate loss of certain neuronal populations. For example, the loss of dopamine (DA) neurons in the substantia nigra pars compacta has been defined as a pathological hallmark of Parkinson’s disease (PD; Kamath et al., 2022). Therefore, methods to reverse neuronal reduction in an effort to rebuild neural circuits and improve function have become an important research focus. In the past decade, regenerative medicine has taken a momentous leap forward with a groundbreaking discovery in the field of neuroregeneration. In vivo glia-to-neuron conversion therapy has presented itself as a potential solution (Qian et al., 2020). This is a paradigm-shifting regenerative strategy to reprogram resident glial cells in situ into neurons in vivo (Figure 1). This method is obviously superior to the strategy of inducing stem cells to differentiate into neurons in vitro for in vivo transplantation, avoiding various problems, such as difficult integration, cancer degeneration, and immunogenicity. However, the evidence supporting the replacement of lost neurons with trans-differentiated cells and\ the reconstitution of neuronal circuits remains limited.