中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (5): 988-997.doi: 10.4103/1673-5374.385284

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

铁死亡:脑卒中的潜在治疗靶点

  

  • 出版日期:2024-05-15 发布日期:2023-10-31

Ferroptosis: a potential therapeutic target for stroke

Chengli Liu#, Guijun Wang#, Wenrui Han, Qi Tian, Mingchang Li*   

  1. Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China
  • Online:2024-05-15 Published:2023-10-31
  • Contact: Mingchang Li, MD, PhD, mingcli@whu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 81971870 and 82172173 (to ML).

摘要:

铁死亡是一种以大量铁离子沉积和铁依赖性脂质过氧化为特征的调节性细胞坏死。铁死亡可引起血红蛋白降解和铁代谢失衡导致的铁超载,被认为是脑卒中后一系列病理生理反应的关键机制。此综述讨论了铁死亡相关的代谢、直接或间接靶向铁代谢和脂质过氧化的重要分子以及铁死亡的转录调控,揭示了铁死亡在脑卒中进展中的作用。文章介绍了干预铁死亡作为脑卒中治疗策略的最新进展,并总结了铁死亡抑制剂对脑卒中的作用。此综述有助于进一步了解脑卒中铁死亡相关的发病机制,并提出治疗脑卒中的新靶点。

https://orcid.org/0000-0003-4019-8886 (Mingchang Li)

Abstract: Ferroptosis is a form of regulated cell death characterized by massive iron accumulation and iron-dependent lipid peroxidation, differing from apoptosis, necroptosis, and autophagy in several aspects. Ferroptosis is regarded as a critical mechanism of a series of pathophysiological reactions after stroke because of iron overload caused by hemoglobin degradation and iron metabolism imbalance. In this review, we discuss ferroptosis-related metabolisms, important molecules directly or indirectly targeting iron metabolism and lipid peroxidation, and transcriptional regulation of ferroptosis, revealing the role of ferroptosis in the progression of stroke. We present updated progress in the intervention of ferroptosis as therapeutic strategies for stroke in vivo and in vitro and summarize the effects of ferroptosis inhibitors on stroke. Our review facilitates further understanding of ferroptosis pathogenesis in stroke, proposes new targets for the treatment of stroke, and suggests that more efforts should be made to investigate the mechanism of ferroptosis in stroke.

Key words: cell death, ferroptosis, oxidative stress, stroke, treatment