中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (5): 939-940.doi: 10.4103/1673-5374.385294

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

α7烟碱受体作为实验性卒中的潜在治疗靶点

  

  • 出版日期:2024-05-15 发布日期:2023-10-31

Alpha7 nicotinic receptors as potential theranostic targets for experimental stroke

Maider Garbizu, Laura Aguado, Abraham Martín*   

  1. Achucarro Basque Center for Neuroscience, Leioa, Spain (Garbizu M, Aguado L, Martín A)
    CIC biomaGUNE, Basque Research and Technology Alliance, San Sebastian, Spain (Garbizu M, Aguado L)
    Ikerbasque Basque Foundation for Science, Bilbao, Spain (Martín A)
  • Online:2024-05-15 Published:2023-10-31
  • Contact: Abraham Martín, PhD, abraham.martin@achucarro.org.

摘要: https://orcid.org/0000-0002-5357-4935 (Abraham Martín)

Abstract: Inflammatory reflex and cholinergic anti-inflammatory pathway: Innate immune system triggers a local inflammatory response following an injury or a pathogen invasion. Likewise, this inflammatory response is limited by rapid, localized, and adaptive anti-inflammatory responses which are crucial for maintaining homeostasis. Hence, the loss of these responses converts a limited and protective inflammatory response into an excessive and harmful response. Anti-inflammatory responses are integrated into the central nervous system, since the central nervous system accumulates information about harmful events, activates defenses, and builds memory for survival. At the same time, it has been demonstrated that hypothalamic neuronal signaling can be altered by inflammation in peripheral tissues. Additionally, immune cells release neuropeptides and neurotransmitters such as acetylcholine (ACh), the main neurotransmitter of the parasympathetic autonomic nervous system, evidencing the communication between the immune and nervous systems (Tracey, 2002).