中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (5): 953-954.doi: 10.4103/1673-5374.385297

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

诱导多能干细胞衍生的脑细胞、类器官、组装体和血脑屏障模型在理解酒精和麻醉剂诱导的脑损伤中的应用:一个新的视角

  

  • 出版日期:2024-05-15 发布日期:2023-10-31

Use of induced pluripotent stem cell-derived brain cells, organoids, assembloids, and blood-brain barrier models in understanding alcohol and anesthetic-induced brain injuries: an emerging perspective

Xiaowen Bai*   

  1. Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA
  • Online:2024-05-15 Published:2023-10-31
  • Contact: Xiaowen Bai, PhD, xibai@mcw.edu.
  • Supported by:
    This work was supported by grants R01 GM112696 and 1R35GM148177 from the National Institutes of Health (to XB), Advancing a Healthier Wisconsin (to XB), and Medical College of Wisconsin-Neuroscience Research Center-Alzheimer’s Award (to XB). 

摘要: https://orcid.org/0000-0002-9342-4480 (Xiaowen Bai)

Abstract: Neurological disorders, including developmental disorders, Alzheimer’s disease (AD), and psychiatric conditions, have significant social and economic impacts globally. Despite extensive research into the underlying mechanisms of these disorders, effective treatments remain elusive, partly due to the complexity of the brain, the limited availability of human brain tissue, and the blood-brain barrier (BBB)’s impermeability to certain drugs. This perspective article discusses the potential of human induced pluripotent stem cell (iPSC)-based models of brain cells, organoids, assembloids, and BBB to advance our understanding of the etiology, progression, and mechanisms of brain injuries induced by alcohol consumption and general anesthesia. These models could also be used to develop protective and therapeutic approaches.