中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (5): 943-944.doi: 10.4103/1673-5374.385299

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

人类钙调素突变的神经后果

  

  • 出版日期:2024-05-15 发布日期:2023-10-31

Neurological consequences of human calmodulin mutations

Helene H. Jensen*, Anders Olsen*   

  1. Medical Biotechnology, Department of Chemistry and Biosciences, Aalborg University, Aalborg, Denmark
  • Online:2024-05-15 Published:2023-10-31
  • Contact: Helene H. Jensen, PhD, hhj@bio.aau.dk; Anders Olsen, PhD, ao@bio.aau.dk.
  • Supported by:
    This work was supported by Lundbeckfonden (R250-2017-134, to HHJ).

摘要: https://orcid.org/0000-0002-8426-9802 (Helene H. Jensen)
https://orcid.org/0000-0002-9613-9722 (Anders Olsen)

Abstract: When calcium ions enter the cytosol, it is a stimulatory signal for cellular events. The calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream interaction partners. In this way, calmodulin affects cellular processes such as fertilization, muscle contraction, neuronal firing, and apoptosis. That is, calmodulin is involved in (nearly) everything! The significance of calmodulin is emphasized by the fact that we all carry three different genes (CALM1,2,3) on different chromosomes that encode the exact same calmodulin protein, and these are all expressed in all cell types. Moreover, throughout vertebrate evolution, the protein sequence has remained completely unchanged.