中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (5): 969-970.doi: 10.4103/1673-5374.385300

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

可生物降解微球脑外渗治疗的前景

  

  • 出版日期:2024-05-15 发布日期:2023-10-31

Perspectives for delivery of therapeutics by extravasation of biodegradable microspheres in the brain

Anne-Eva van der Wijk, Ed VanBavel*   

  1. Amsterdam UMC location University of Amsterdam, Department of Biomedical Engineering and Physics, Amsterdam, The Netherlands (van der Wijk AE, VanBavel E) 
    Amsterdam Neuroscience, Neurovascular Disorders Program, Amsterdam, The Netherlands (van der Wijk AE, VanBavel E)
    Amsterdam Cardiovascular Sciences, Microcirculation Program, Amsterdam, The Netherlands (van der Wijk AE, VanBavel E)
  • Online:2024-05-15 Published:2023-10-31
  • Contact: Ed VanBavel, PhD, e.vanbavel@amsterdamumc.nl.
  • Supported by:
    This work was supported by Amsterdam Neuroscience (project number NDIS-2019-03, to AEW and EVB). 

摘要: https://orcid.org/0000-0001-8654-986X (Ed VanBavel)

Abstract: Development of therapeutics for brain diseases has remained challenging, in particular due to the difficulty of passing the blood-brain barrier. As a result, the current arsenal of therapeutics targeting the brain is limited to small, lipid-soluble drugs and there is a lack of options for treating neuroblastomas, Alzheimer’s disease, and many other devastating pathologies. Despite the advances in strategies for crossing the blood-brain barrier such as the use of nanoparticles (Hersh et al., 2022; Duan et al., 2023), such delivery systems have not yet reached clinical practice. Therefore, novel platforms for the transport of therapeutics across the blood-brain barrier remain highly desired. This specifically holds for large molecules such as monoclonal antibodies and recombinant proteins, as well as nucleotide-based therapeutics and cell therapies. Research efforts in this field are increasing exponentially, with thousands of publications in the last few years.