中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (6): 1187-1188.doi: 10.4103/1673-5374.385856

• 观点:退行性病与再生 • 上一篇    下一篇

ZEB1-AS1洞察:从癌症到神经退行性变的新作用

  

  • 出版日期:2024-06-15 发布日期:2023-11-17

Insights on ZEB1-AS1: emerging roles from cancer to neurodegeneration

Stephana Carelli*, #, Federica Rey#, Erika Maghraby#, Cristina Cereda##br#   

  1. Pediatric Research Center “Romeo ed Enrica Invernizzi”, Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy (Carelli S, Rey F, Maghraby E) 
    Center of Functional Genomics and Rare Diseases, Department of Pediatrics, Buzzi Children’s Hospital, Milan, Italy (Carelli S, Rey F, Cereda C) 
    Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia, Italy (Maghraby E) 
  • Online:2024-06-15 Published:2023-11-17
  • Contact: Stephana Carelli, PhD, stephana.carelli@unimi.it.
  • Supported by:
    This work was partially funded by Fondazione Regionale per la Ricerca Biomedica (TRANS-ALS; 2015-0023); and Fondazione “Romeo and Enrica Invernizzi” (to SC and CC).

摘要: https://orcid.org/0000-0003-4603-396X (Stephana Carelli) 

Abstract: Implications for lncRNAs in the central nervous system: Transcriptional dysregulation is a key contributor to the pathogenesis of a wide range of diseases and long non-coding RNAs (lncRNAs) are highly expressed in the nervous system. Indeed, amongst the over 50,000 lncRNAs expressed in the human genome, more than 40% are specifically expressed in the brain where their roles in brain development, neuron functions, maintenance, and differentiation, are becoming increasingly evident (Zhou et al., 2021). In addition, some lncRNAs were found to have a role in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and Alzheimer’s disease, along with an interesting link to the physiological aging process (Rey et al., 2021; Zhou et al., 2021). Interestingly, RNA-sequencing analysis conducted in peripheral blood mononuclear cells of sporadic ALS patients and matched controls highlighted 293 differentially expressed lncRNAs contributing to corroborate the importance of lncRNAs in ALS (Gagliardi et al., 2018). Amongst the top ten deregulated lncRNAs identified the most dysregulated antisense of transcription-related genes was Zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1), antisense to the ZEB1 gene (Gagliardi et al., 2018, Garofalo et al., 2020).