中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (6): 1179-1180.doi: 10.4103/1673-5374.385862

• 观点:退行性病与再生 • 上一篇    下一篇

成像质谱:用于研究脂质在帕金森病中作用的分子显微镜

  

  • 出版日期:2024-06-15 发布日期:2023-11-17

Imaging mass spectrometry: a molecular microscope for studying the role of lipids in Parkinson’s disease

Vinata Vedam-Mai*, Jacob M. Samuel, Boone M. Prentice   

  1. Department of Neurology, University of Florida, Gainesville, FL, USA (Vedam-Mai V) 
    Department of Chemistry, University of Florida, Gainesville, FL, USA (Samuel JM, Prentice BM) 
  • Online:2024-06-15 Published:2023-11-17
  • Contact: Vinata Vedam-Mai, PhD, vinved@ufl.edu.

摘要: https://orcid.org/0000-0003-0148-3297 (Vinata Vedam-Mai)

Abstract: Parkinson’s disease–A lipidopathy? The histopathological hallmark of Parkinson’s disease (PD) and dementia with Lewy bodies are inclusions enriched in α-synuclein (α-syn), known as Lewy bodies, which are not only composed of proteins, but also a core of lipid species. PD has been thus far principally thought of as a “proteinopathy” caused by the misfolding of α-syn. However, there is a major role for certain lipids in modulating α-syn physiology in the brain and both decreased and increased membrane interactions and interactions with specific fatty acids are potential triggers for α-syn oligomerization and fibril formation. Alterations in lipid homeostasis have been observed in several brain regions that show pathology and PD should be considered not only a proteinopathy but also a lipidopathy due to the following: 
1. Lipids/membranes are core components of Lewy bodies;
2. Lipid proportions in organelles affect the α-syn structure and lipid-binding properties; 
3. Lipid dyshomeostasis is linked to impaired organelle function;
4. Lipid accumulation in neurons and parenchyma are associated with neuroinflammation;
5. Lipid metabolism genes have been identified as risk factors for PD. 
Hence, a comprehensive analysis of the brain lipidome, in combination with genomics and proteomics, promises a more holistic view of brain chemistry and can aid in the discovery of biomarkers for diagnosing and monitoring diseases.