中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (7): 1415-1416.doi: 10.4103/1673-5374.387989

• 观点:退行性病与再生 • 上一篇    下一篇

NELF-A和RNA聚合酶II延伸对衰老的调控

  

  • 出版日期:2024-07-15 发布日期:2023-11-28

Regulation of aging by NELF-A and RNA polymerase II elongation

Chin-Tong Ong*, Zhen-Kai Ngian   

  1. Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore, Singapore (Ong CT) 
    Department of Genetics, Harvard Medical School, Boston, MA, USA (Ngian ZK) 
    Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore (Ngian ZK)
  • Online:2024-07-15 Published:2023-11-28
  • Contact: Chin-Tong Ong, PhD, chintong@tll.org.sg.
  • Supported by:
    This work was supported by core funding provided by Temasek Life Sciences Laboratory (to CTO).

摘要: https://orcid.org/0000-0002-5450-4760 (Chin-Tong Ong)

Abstract: Epigenetic regulation of aging: Aging is defined as the gradual decline of physiological function and cellular integrity, causing organismal vulnerability to age-onset diseases and morbidity. Studies in different animal models have led to the identification of twelve aging hallmarks that shared several features: its age-associated manifestation, how experimental manipulation of individual hallmark may alter the trajectory of aging, as well as their interdependence during the process of aging. These hallmarks include genomic instability, telomere attrition, loss of proteostasis, disabled macro-autophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, chronic inflammation, dysbiosis, altered intercellular communication and epigenetic alterations (Lopez-Otin et al., 2023).