中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (7): 1423-1424.doi: 10.4103/1673-5374.387990

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

建立重复经颅磁刺激的综合可塑性/网络框架为量身定制的治疗提供信息

  

  • 出版日期:2024-07-15 发布日期:2023-11-28

Working toward an integrated plasticity/network framework for repetitive transcranial magnetic stimulation to inform tailored treatments

Jessica Moretti*, Jennifer Rodger   

  1. Experimental and Regenerative Neurosciences, School of Biological Sciences, University of Western Australia, Crawley, WA, Australia 
    (Moretti J, Rodger J)
    Brain Plasticity Lab, Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia (Moretti J, Rodger J)
  • Online:2024-07-15 Published:2023-11-28
  • Contact: Jessica Moretti, PhD, jmoretti.research@gmail.com.
  • Supported by:
    This work was supported by the Bryant Stokes Neurological Research Fund (to JM); a fellowship from Multiple Sclerosis Western Australia (MSWA), the Perron Institute for Neurological and Translational Science, and the Bryant Stokes Neurological Research Fund (to JR).

摘要: https://orcid.org/0000-0001-8243-9540 (Jessica Moretti)

Abstract: Non-invasive brain stimulation techniques (NIBS), including repetitive transcranial magnetic stimulation (rTMS) and transcranial electric stimulation (tES), are increasingly being adopted clinically for treatment of neuropsychiatric and neurological disorders, albeit with varying success. The rationale behind the use of NIBS has historically been that stimulation techniques modulate neuronal activity in the targeted region and consequently induce plasticity which can lead to therapeutic outcomes. However, over the past decade, there has been a marked increase in our understanding of the neurobiological mechanisms of NIBS, in particular for rTMS. The increasing breadth of research in humans and animal models has resulted in a more nuanced understanding of how NIBS affects the brain with the hope for improved therapeutic applications. In this perspective we summarize some of the newly identified mechanisms contributing to NIBS effects, focusing on rTMS, and propose how emerging experimental techniques could be leveraged to further understand and optimize non-invasive brain stimulation.