中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (7): 1419-1420.doi: 10.4103/1673-5374.387994

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

顽固性癫痫中异常的成年神经发生:GABA能祖细胞移植能否使这一过程正常化?

  

  • 出版日期:2024-07-15 发布日期:2023-11-28

Aberrant adult neurogenesis in intractable epilepsy: can GABAergic progenitor transplantation normalize this process?

Muhammad N. Arshad, Janice R. Naegele*#br#   

  1. Department of Biology, Wesleyan University, Middletown, CT, USA (Arshad MN, Naegele JR)
    Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA (Arshad MN)
  • Online:2024-07-15 Published:2023-11-28
  • Contact: Janice R. Naegele, PhD, jnaegele@wesleyan.edu.

摘要: https://orcid.org/ 0000-0001-5151-0543 (Janice R. Naegele)

Abstract: Temporal lobe epilepsy (TLE) is a common type of focal epilepsy characterized by seizure foci within the temporal lobes. While surgical resection of the foci is an established and effective approach for controlling seizures, both temporal lobes cannot be removed, due to their prominent roles in learning and memory. Additionally, seizures induce changes to the temporal lobes that contribute to hyperexcitability, including mossy fiber sprouting, astrogliosis, granule cell (GC) dispersion, and loss of amma-aminobutyric acid (GABA)ergic interneurons (Swartz et al., 2006; Ammothumkandy et al., 2022).