中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (8): 1696-1701.doi: 10.4103/1673-5374.389364

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

Snapin蛋白在调节脑稳态中的作用

  

  • 出版日期:2024-08-15 发布日期:2024-01-03
  • 基金资助:
    国自然;江苏省高等学校优先发展学科项目(PAPD);江苏省333高层次人才培养工程(2022);江苏省妇幼卫生研究重点项目; 江苏省青年医学英才计划;上海市法医学重点实验室;苏州市科技发展项目

The role of snapin in regulation of brain homeostasis

Jiawen Li1, 2, #, Xinqi Huang2, #, Yumei An2, #, Xueshi Chen2, Yiyang Chen2, Mingyuan Xu2, Haiyan Shan3, *, Mingyang Zhang1, 2, *   

  1. 1Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, China (Academy of Forensic Science), Shanghai, China; 2Institute of Forensic Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu Province, China; 3Department of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Mingyang Zhang, MD, PhD, mingyangzhang@suda.edu.cn; Haiyan Shan, MD, PhD, ghostqth@163.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 82071382 (to MZ), 81601306 (to HS); the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) (to MZ); Jiangsu 333 High Level Talent Training Project (2022) (to HS); the Jiangsu Maternal and Child Health Research Key Project (F202013) (to HS); Jiangsu Talent Youth Medical Program, No. QNRC2016245 (to HS); Shanghai Key Lab of Forensic Medicine, No. KF2102 (to MZ); Suzhou Science and Technology Development Project, No. SYS2020089 (to MZ); the Fifth Batch of Gusu District Health Talent Training Project, No. GSWS2019060 (to HS).

摘要:

脑稳态是指大脑在一定时间内的正常工作状态,对于人体的健康和正常生命活动具有重要意义。目前针对脑稳态失调所带来的不良后果,尚缺乏有效的治疗方法。近期,许多研究人员报道snapin蛋白与神经和精神疾病之间的关联性,并发现该蛋白能够改善脑稳态。Snapin是一种辅助神经元突触形成的蛋白质,在神经元突触的正常发育和成长中起着关键作用。中枢神经系统疾病引起的临床表现往往包括脑稳态失衡以及可能出现的神经认知和行为缺陷后遗症。文章通过收集整合以往有关脑稳态,Snapin和中枢神经系统疾病的文献。首先主要介绍了snapin在神经系统功能调节中的作用,包括调节神经递质释放过程中的囊泡融合、释放过程的步骤和强度;随后介绍了Snapin通过结合Cypin、SPAG6、Dynein和AC6等蛋白调节神经元生长发育的作用,以及调控自噬溶酶体系统;还介绍了Snapin对阿尔茨海默病、精神分裂症和其他脑内疾病的治疗意义,总结了snapin在稳定脑稳态中的作用机制;最后,补充了Snapin对全身性疾病(包括糖尿病、病毒感染性疾病)的意义。最后提出了目前Snapin相关研究存在的问题以及团队未来的研究方向,为脑功能紊乱患者恢复脑稳态提供了一个新的有潜力的靶点。

https://orcid.org/0000-0001-7084-6237 (Mingyang Zhang); https://orcid.org/0000-0002-6832-7363 (Haiyan Shan)

Abstract: Brain homeostasis refers to the normal working state of the brain in a certain period, which is important for overall health and normal life activities. Currently, there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis imbalance. Snapin is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of synapses. Recently, many researchers have reported the association between snapin and neurologic and psychiatric disorders, demonstrating that snapin can improve brain homeostasis. Clinical manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral sequelae. This article aims to explore the role of snapin in restoring brain homeostasis after injury or diseases, highlighting its significance in maintaining brain homeostasis and treating brain diseases. Additionally, it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections, with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.

Key words: brain homeostasis, diabetes, neurological diseases, snapin, traumatic brain injury, vesicle fusion