中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (8): 1702-1706.doi: 10.4103/1673-5374.389627

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

用于神经刺激的毫米仪器:小型化的一条有前途的道路

  

  • 出版日期:2024-08-15 发布日期:2024-01-03

Millimetric devices for nerve stimulation: a promising path towards miniaturization

Ryan M. Dorrian1, Anna V. Leonard1, Antonio Lauto2, *   

  1. 1Spinal Cord Injury Research Group, School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia; 2School of Science, Western Sydney University, Penrith, NSW, Australia
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Antonio Lauto, PhD, A.Lauto@westernsydney.edu.au.
  • Supported by:
    This work was funded by Western Sydney University and The University of Adelaide. The authors are also supported by the Morton Cure Paralysis Fund and the Neurosurgical Research Foundation.

摘要: https://orcid.org/0000-0003-4593-5603 (Antonio Lauto)

Abstract: Nerve stimulation is a rapidly developing field, demonstrating positive outcomes across several conditions. Despite potential benefits, current nerve stimulation devices are large, complicated, and are powered via implanted pulse generators. These factors necessitate invasive surgical implantation and limit potential applications. Reducing nerve stimulation devices to millimetric sizes would make these interventions less invasive and facilitate broader therapeutic applications. However, device miniaturization presents a serious engineering challenge. This review presents significant advancements from several groups that have overcome this challenge and developed millimetric-sized nerve stimulation devices. These are based on antennas, mini-coils, magneto-electric and opto-electronic materials, or receive ultrasound power. We highlight key design elements, findings from pilot studies, and present several considerations for future applications of these devices.

Key words: biomedical engineering, deep brain stimulation, electrical engineering, electrical stimulation, neuromodulation, peripheral nerve stimulation