中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (8): 1629-1630.doi: 10.4103/1673-5374.389635

• 观点:退行性病与再生 •    下一篇

新的药理学工具:利用二萜促进成年海马神经发生

  

  • 出版日期:2024-08-15 发布日期:2024-01-03

New pharmacological tools: the use of diterpenes to promote adult hippocampal neurogenesis

Ricardo Gómez-Oliva, Pedro Nunez-Abades, Carmen Castro*#br#   

  1. Department of Biomedicine, Biotechnology and Public Health, Division of Physiology, University of Cadiz, Cadiz, Spain (Gómez-Oliva R, Castro C) 
    Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain (Gómez-Oliva R, Nunez-Abades P, Castro C) 
    Department of Physiology, University of Seville, Seville, Spain (Nunez-Abades P)
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Carmen Castro, PhD, carmen.castro@uca.es.
  • Supported by:
    This work was supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (grant number RTI-2018-099908-B-C21 and RTI-2018-099908-B-C22 granted to CC), by the Consejería de Economía, Conocimiento, Empresas y Universidades (grant number FEDER-UCA18-106647 granted to CC) and by the Consejería de Salud y Familias 80% co-financed  by EDRF ITI regional funds (ITI-Cadiz-0042-2019 to CC).

摘要: https://orcid.org/0000-0002-6802-0572 (Carmen Castro)

Abstract: Tissue regeneration maintains homeostasis and preserves the functional features of each tissue. However, not all tissues show a strong repairing capacity. This is the case of the central nervous system. It is now well established that the generation of new functional neurons from stem cells in the adult brain occurs in specific regions of the brain of different species such as rodents, birds, primates, and humans (Eriksson et al., 1998). The brain areas in which neurogenesis occurs are referred to as neurogenic niches, regions in which neural stem cells (NSC) are surrounded by cells and signaling molecules that lead their fate toward mature neurons. Two main neurogenic niches have been thoroughly described in adult rodents: the subventricular zone and the dentate gyrus of the hippocampus (DG). NSC in the adult DG remain mainly in a quiescent non-proliferative state (qNSC) and are able to generate neurons through a complex hierarchical process that involves the activation of neural stem cells, the generation of undifferentiated progenitors, and the origination of immature neurons that differentiate into mature functional neurons. Newly generated neurons migrate short distances from the subgranular zone to the granular layer, where through their axons, they integrate into pre-existing circuits by establishing connections with CA3 and CA2 regions. These neurons participate in several tasks that involve the hippocampus such as memory consolidation, spatial and temporal pattern discrimination, or forgetting, among others.