中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (9): 1967-1972.doi: 10.4103/1673-5374.390962

• 综述:退行性病与再生 • 上一篇    下一篇

昼夜节律紊乱和视网膜功能障碍:阿尔茨海默病的双向联系?

  

  • 出版日期:2024-09-15 发布日期:2024-01-25

Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer’s disease?

Laura Carrero1, 2, Desireé Antequera3, Cristina Municio1, *, Eva Carro3, *   

  1. 1Group of Neurodegenerative Diseases, Hospital Universitario 12 de Octubre Research Institute (imas12), Madrid, Spain; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, Madrid, Spain; 2PhD Program in Neuroscience, Autonoma de Madrid University, Madrid, Spain; 3Neurobiology of Alzheimer’s Disease Unit, Functional Unit for Research into Chronic Diseases, Instituto de Salud Carlos III, Madrid, Spain; Network Centre for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, Madrid, Spain
  • Online:2024-09-15 Published:2024-01-25
  • Contact: Eva Carro, PhD, eva.carro@isciii.es; Cristina Municio, PhD, c.municio@externos.isciii.es.

摘要: https://orcid.org/0000-0002-6504-4579 (Eva Carro); https://orcid.org/0000-0002-8552-8183 (Cristina Municio)

Abstract: Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer’s disease. A predominant function of the retina is circadian synchronization, carrying information to the brain through the retinohypothalamic tract, which projects to the suprachiasmatic nucleus. Notably, Alzheimer’s disease hallmarks, including amyloid-β, are present in the retinas of Alzheimer’s disease patients, followed/associated by structural and functional disturbances. However, the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer’s disease is not fully understood, although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm. 

Key words: Alzheimer’s disease, amyloid, circadian rhythm, neurodegeneration, retina