中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (9): 1940-1946.doi: 10.4103/1673-5374.390968

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

人工冬眠在急性脑损伤中的应用

  

  • 出版日期:2024-09-15 发布日期:2024-01-25
  • 基金资助:
    国防科技杰出青年科学基金项目(2021-JCJQ-ZQ-035);国防创新特区项目(21-163-12-ZT-006-002-13);国家自然科学基金重点项目(11932013)

Application of artificial hibernation technology in acute brain injury

Xiaoni Wang1, #, Shulian Chen2, #, Xiaoyu Wang2, #, Zhen Song1, Ziqi Wang1, Xiaofei Niu1, Xiaochu Chen2, *, Xuyi Chen2, *   

  1. 1Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin, China; 2Characteristic Medical Center of People’s Armed Police Forces, Tianjin, China
  • Online:2024-09-15 Published:2024-01-25
  • Contact: Xiaochu Chen, MS, cc_asdler@163.com; Xuyi Chen, MD, chenxuyi1979@126.com.
  • Supported by:
    This work was supported by the National Defense Science and Technology Outstanding Youth Science Fund Project, No. 2021-JCJQ-ZQ-035; National Defense Innovation Special Zone Project, No. 21-163-12-ZT-006-002-13; Key Program of the National Natural Science Foundation of China, No. 11932013 (all to XuC).

摘要:

控制颅内压、神经细胞再生和微环境调节是降低急性脑损伤死亡率和致残率的主要手段,目前尚缺乏有效的治疗方法。冬眠具有低温、低代谢和冬眠节律的特点,同时对神经、心血管和运动系统具有保护作用。人工冬眠可通过改变人体新陈代谢,降低人体核心温度,让人体进入类似冬眠的状态,从而有效治疗急性脑损伤。此次综述介绍了人工冬眠技术,包括轻度低体温治疗技术、中枢神经系统调节技术和人工冬眠诱导技术;通过总结人工冬眠技术在急性脑损伤中的相关研究,认为人工冬眠技术具有神经保护、抗炎、抗氧化应激等作用,对急性脑损伤具有治疗意义。然而,人工休眠技术目前尚不成熟,存在并发症等各种缺陷,其临床应用效果还需要进一步的研究。

https://orcid.org/0009-0005-4861-5412 (Xiaochu Chen); https://orcid.org/0000-0002-0420-8349 (Xuyi Chen)

Abstract: Controlling intracranial pressure, nerve cell regeneration, and microenvironment regulation are the key issues in reducing mortality and disability in acute brain injury. There is currently a lack of effective treatment methods. Hibernation has the characteristics of low temperature, low metabolism, and hibernation rhythm, as well as protective effects on the nervous, cardiovascular, and motor systems. Artificial hibernation technology is a new technology that can effectively treat acute brain injury by altering the body’s metabolism, lowering the body’s core temperature, and allowing the body to enter a state similar to hibernation. This review introduces artificial hibernation technology, including mild hypothermia treatment technology, central nervous system regulation technology, and artificial hibernation-inducer technology. Upon summarizing the relevant research on artificial hibernation technology in acute brain injury, the research results show that artificial hibernation technology has neuroprotective, anti-inflammatory, and oxidative stress-resistance effects, indicating that it has therapeutic significance in acute brain injury. Furthermore, artificial hibernation technology can alleviate the damage of ischemic stroke, traumatic brain injury, cerebral hemorrhage, cerebral infarction, and other diseases, providing new strategies for treating acute brain injury. However, artificial hibernation technology is currently in its infancy and has some complications, such as electrolyte imbalance and coagulation disorders, which limit its use. Further research is needed for its clinical application.

Key words: acute brain injury, artificial hibernation, hypothermia, low metabolism, mild hypothermia