中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (11): 2387-2399.doi: 10.4103/1673-5374.390972

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

人脑类器官:趋势、进化和依然存在的挑战

  


  • 出版日期:2024-11-15 发布日期:2024-03-29

Human brain organoid: trends, evolution, and remaining challenges

Minghui Li1, 2, *, Yuhan Yuan1, Zongkun Hou3, Shilei Hao1, *, Liang Jin1, *, Bochu Wang1, *   

  1. 1Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China; 2Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China; 3School of Biology and Engineering/School of Basic Medical Sciences, Guizhou Medical University, Guiyang, Guizhou Province, China
  • Online:2024-11-15 Published:2024-03-29
  • Contact: Minghui Li, PhD, mhli1988@outlook.com; Shilei Hao, PhD, shilei_hao@cqu.edu.cn; Liang Jin, jinliang4002@126.com; Bochu Wang, PhD, wangbc@cqu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 82204083 (to ML) and 12372303 (to BW); the Natural Science Foundation of Chongqing, No. cstc2021jcy-jmsxmX0171 (to ML).

摘要: 人类脑器官的研究为破译人类神经发育和疾病的分子生物学过程提供了一个有前景的平台。虽然已有文章描述了类脑器官的发展和进步,但很少有研究全面总结和分析其在神经科学的全球发展趋势。为了充分认识和进一步促进类脑器官的发展,文章利用文献计量学和可视化方法分析了近十年来全球类脑器官的发展趋势和演变。首先,阐述了类脑器官的年度出版物、国家/地区、组织、期刊、作者、共被引和关键词等信息和该领域的研究热点。随后,全面讨论了目前类脑器官在神经科学中的应用,包括在人类神经发育、神经疾病、传染病、再生医学、药物发现和毒性评估中的应用。此外,文章将对类脑器官目前面临的挑战和未来神经科学领域的发展策略提出几点考虑,以进一步促进其在神经学研究中的发展。尽管近十年来类脑器官技术在神经科学领域发展迅速,为各种神经系统疾病和人类大脑发育机制的破译提供了有极具前景的模型,但这一研究领域仍处于发展和初级阶段,存在一些局限性和问题需要解决。因此,研究创新,包括新思维,新技术和新方法,如基因编辑和生物工程手段,将有助于类脑器官研究的进展和医学应用。

https://orcid.org/0000-0002-0098-6848 (Minghui Li); https://orcid.org/0000-0003-1205-3102 (Shilei Hao); 

https://orcid.org/0000-0002-0592-3264 (Bochu Wang)

Abstract: Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and diseases. Although various studies and reviews have described developments and advancements in brain organoids, few studies have comprehensively summarized and analyzed the global trends in this area of neuroscience. To identify and further facilitate the development of cerebral organoids, we utilized bibliometrics and visualization methods to analyze the global trends and evolution of brain organoids in the last 10 years. First, annual publications, countries/regions, organizations, journals, authors, co-citations, and keywords relating to brain organoids were identified. The hotspots in this field were also systematically identified. Subsequently, current applications for brain organoids in neuroscience, including human neural development, neural disorders, infectious diseases, regenerative medicine, drug discovery, and toxicity assessment studies, are comprehensively discussed. Towards that end, several considerations regarding the current challenges in brain organoid research and future strategies to advance neuroscience will be presented to further promote their application in neurological research.

Key words: bibliometric analysis, brain organoids, cerebral organoids, global trends, neuroscience