中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (11): 2325-2326.doi: 10.4103/1673-5374.391333

• 观点:退行性病与再生 •    下一篇

鞘脂信息促进神经元跨代健康

  

  • 出版日期:2024-11-15 发布日期:2024-03-28

A sphingolipid message promotes neuronal health across generations

Wenyue Wang*, Roger Pocock*   

  1. Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC, Australia
  • Online:2024-11-15 Published:2024-03-28
  • Contact: Roger Pocock, PhD, roger.pocock@monash.edu; Wenyue Wang, PhD, wenyue.wang1@monash.edu.
  • Supported by:
    This work was supported by the National Health and Medical Research Council grants GNT1105374, GNT1137645 and GNT2000766 (to RP).

摘要: https://orcid.org/0000-0002-5515-3608 (Roger Pocock)

Abstract: Maternal nutrition can affect brain function of offspring in later life (Fitzgerald et al., 2020). Emerging studies have also shown that the maternal environment can modify susceptibility to neurodegenerative disease (Boots et al., 2023). Transmission of environmental information from mother to offspring depends on maternal nutrient provisioning. In the nematode Caenorhabditis elegans, maternal yolk, which is synthesized in the intestine and transferred to nourish oocytes and early embryos, can provide extranuclear inheritance factors to mediate phenotypic plasticity across generations. However, the molecular mechanisms of regulating such intergenerational effects remain largely unknown.