中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (1): 67-81.doi: 10.4103/1673-5374.393104

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

缺血性脑卒中炎症反应机制和干细胞治疗效果:当前证据与未来展望

  

  • 出版日期:2025-01-15 发布日期:2025-01-15

Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke: current evidence and future perspectives

Yubo Wang1, 2, #, Tingli Yuan3, #, Tianjie Lyu1, 2, #, Ling Zhang1, Meng Wang2, 4, Zhiying He3, 5, *, Yongjun Wang1, 2, 4, 6, 7, 8, *, Zixiao Li1, 2, 4, 6, 7, 8, *   

  1. 1Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; 2China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; 3Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai, China; 4National Center for Healthcare Quality Management in Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; 5Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China; 6Chinese Institute for Brain Research, Beijing, China; 7Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, China; 8Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases, Beijing, China
  • Online:2025-01-15 Published:2025-01-15
  • Contact: Zhiying He, PhD, zyhe@tongji.edu.cn; Yongjun Wang, PhD, MD, yongjunwang@ncrcnd.org.cn; Zixiao Li, PhD, MD, lizixiao2008@hotmail.com.
  • Supported by:
    This work was supported by grants from the Major Program of National Key Research and Development Project, Nos. 2020YFA0112600 (to ZH); the National Natural Science Foundation of China, No. 82171270 (to ZL); Public Service Platform for Artificial Intelligence Screening and Auxiliary Diagnosis for the Medical and Health Industry, Ministry of Industry and Information Technology of the People's Republic of China, No. 2020-0103-3-1 (to ZL); the Natural Science Foundation of Beijing, No. Z200016 (to ZL); Beijing Talents Project, No. 2018000021223ZK03 (to ZL); Beijing Municipal Committee of Science and Technology, No. Z201100005620010 (to ZL); CAMS Innovation Fund for Medical Sciences, No. 2019-I2M-5-029 (to YW); and Shanghai Engineering Research Center of Stem Cells Translational Medicine, No. 20DZ2255100 (to ZH).

摘要:

缺血性脑卒中发生后患者外周免疫系统和中枢神经系统发生一系列病理变化,这些病理变化与患者预后高度相关。干细胞治疗作为一种新型治疗技术,在免疫系统和神经系统疾病治疗中展现出巨大的潜力。文章总结了缺血性卒中发生后不同时期神经系统和免疫系统的病理生理变化,并讨论了干细胞在其中发挥的治疗作用及可能的作用机制,同时概括了不同种类干细胞在卒中治疗应用方面的优缺点及其临床应用前景。了解缺血性卒中后的病理生理变化,炎症反应和干细胞治疗的前景,有助于进一步为缺血性卒中寻找潜在的治疗策略。干细胞具有炎症抑制、免疫调节、神经保护、促进血管再生或分化为神经细胞发挥替代损伤神经元等作用,研究明确不同病理期的特征将有助于干细胞治疗研究中,介入时间点、给药方式、给药次数的设计,可以为干细胞临床应用提供理论支持。

https://orcid.org/0000-0002-0087-2277 (Zhiying He); https://orcid.org/0000-0002-9976-2341 (Yongjun Wang); 

https://orcid.org/0000-0002-4713-5418 (Zixiao Li) 

Abstract: Ischemic stroke is a leading cause of death and disability worldwide, with an increasing trend and tendency for onset at a younger age. China, in particular, bears a high burden of stroke cases. In recent years, the inflammatory response after stroke has become a research hotspot: understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its treatment. This review summarizes several major cells involved in the inflammatory response following ischemic stroke, including microglia, neutrophils, monocytes, lymphocytes, and astrocytes. Additionally, we have also highlighted the recent progress in various treatments for ischemic stroke, particularly in the field of stem cell therapy. Overall, understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient outcomes. Stem cell therapy may potentially become an important component of ischemic stroke treatment.

Key words: cell therapy, immune cell, inflammatory, ischemic stroke, stem cell