中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (11): 2421-2429.doi: 10.4103/1673-5374.393107

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

铜进入大脑的机制:许多悬而未决的问题

  

  • 出版日期:2024-11-15 发布日期:2024-03-29

Mechanism of Cu entry into the brain: many unanswered questions

Shubhrajit Roy*, Svetlana Lutsenko*#br#

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  1. Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • Online:2024-11-15 Published:2024-03-29
  • Contact: Shubhrajit Roy, PhD, sroy30@jhmi.edu; Svetlana Lutsenko, PhD, lutsenko@jhmi.edu.
  • Supported by:
    This work was supported by the National Institute of Health grant R01 GM101502 (to SL).

摘要: https://orcid.org/0000-0001-7914-7723 (Shubhrajit Roy); https://orcid.org/0000-0001-5275-2587 (Svetlana Lutsenko)

Abstract: Brain tissue requires high amounts of copper (Cu) for its key physiological processes, such as energy production, neurotransmitter synthesis, maturation of neuropeptides, myelination, synaptic plasticity, and radical scavenging. The requirements for Cu in the brain vary depending on specific brain regions, cell types, organism age, and nutritional status. Cu imbalances cause or contribute to several life-threatening neurologic disorders including Menkes disease, Wilson disease, Alzheimer’s disease, Parkinson’s disease, and others. Despite the well-established role of Cu homeostasis in brain development and function, the mechanisms that govern Cu delivery to the brain are not well defined. This review summarizes available information on Cu transfer through the brain barriers and discusses issues that require further research. 

Key words: ATOX1, ATP7A, ATP7B, blood-brain barrier, brain, choroid plexus, copper, SLC31A1