中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (11): 2456-2466.doi: 10.4103/NRR.NRR-D-23-01470

• 综述:退行性病与再生 • 上一篇    下一篇

异构体和细胞状态特异性APOE稳态和功能

  

  • 出版日期:2024-11-15 发布日期:2024-03-29

Isoform- and cell-state-specific APOE homeostasis and function

Karina Lindner1, 2, Anne-Claude Gavin1, 2, *   

  1. 1Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland; 2Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
  • Online:2024-11-15 Published:2024-03-29
  • Contact: Anne-Claude Gavin, PhD, anne-claude.gavin@unige.ch.
  • Supported by:
    This work was supported by the financial support of the Louis-Jeantet Foundation (to ACG).

摘要: https://orcid.org/0000-0003-4917-2340 (Anne-Claude Gavin)

Abstract: Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling. It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them. Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-onset Alzheimer’s disease. In this review, we discuss our current knowledge of how apolipoprotein E homeostasis, i.e. its synthesis, secretion, degradation, and lipidation, is affected in Alzheimer’s disease.

Key words: Alzheimer’s disease, apolipoprotein E, autophagy, cholesterol, lipid detoxification, lipid transport, lysosomal failure, metabolic impairment, triacylglycerol