中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (11): 2377-2386.doi: 10.4103/NRR.NRR-D-23-01614

• 综述:退行性病与再生 • 上一篇    下一篇

GEMIN5 的功能和功能障碍:了解一种新型神经发育障碍

  

  • 出版日期:2024-11-15 发布日期:2024-03-29

Function and dysfunction of GEMIN5: understanding a novel neurodevelopmental disorder

Charles H. Nelson1, Udai B. Pandey1, 2, *   

  1. 1Department of Pediatrics, Division of Child Neurology, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 2Children’s Neuroscience Institute, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
  • Online:2024-11-15 Published:2024-03-29
  • Contact: Udai B. Pandey, PhD, udai@pitt.edu.
  • Supported by:
    This work was supported by the U.S. National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS), No. R01 NS134215 (to UBP).

摘要: https://orcid.org/0000-0002-6267-0179 (Udai B. Pandey)

Abstract: The recent identification of a neurodevelopmental disorder with cerebellar atrophy and motor dysfunction (NEDCAM) has resulted in an increased interest in GEMIN5, a multifunction RNA-binding protein. As the largest member of the survival motor neuron complex, GEMIN5 plays a key role in the biogenesis of small nuclear ribonucleoproteins while also exhibiting translational regulatory functions as an independent protein. Although many questions remain regarding both the pathogenesis and pathophysiology of this new disorder, considerable progress has been made in the brief time since its discovery. In this review, we examine GEMIN5 within the context of NEDCAM, focusing on the structure, function, and expression of the protein specifically in regard to the disorder itself. Additionally, we explore the current animal models of NEDCAM, as well as potential molecular pathways for treatment and future directions of study. This review provides a comprehensive overview of recent advances in our understanding of this unique member of the survival motor neuron complex.

Key words: cerebellar atrophy, GEMIN5, neurodevelopmental disorder, neurological disease, SMN complex