中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (1): 207-208.doi: 10.4103/NRR.NRR-D-23-01630

• 观点:退行性病与再生 • 上一篇    下一篇

亨廷顿舞蹈症患者中扣带皮层的神经胶质反应

  

  • 出版日期:2025-01-15 发布日期:2025-01-15

Glial response in the midcingulate cortex in Huntington’s disease

Thulani H. Palpagama, Andrea Kwakowsky*   

  1. Center for Brain Research and Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand (Palpagama TH, Kwakowsky A)
    Pharmacology and Therapeutics, School of Medicine, Galway Neuroscience Center, University of Galway, Galway, Ireland (Kwakowsky A) 
  • Online:2025-01-15 Published:2025-01-15
  • Contact: Andrea Kwakowsky, PhD, andrea.kwakowsky@universityofgalway.ie.

摘要: https://orcid.org/0000-0002-3801-4956 (Andrea Kwakowsky) 

Abstract: Huntington’s disease (HD) is a genetic disease characterized by the progressive degeneration of the striatum and cortex. Patients can present with a variety of symptoms that can broadly be classified into motor symptoms, inclusive of choreatic movements and rigidity, mood and psychiatric symptoms, such as depression and apathy, and cognitive symptoms, such as cognitive decline. The causal mutation underlying HD results from an expansion of a CAG repeat sequence on the IT15 gene, resulting in the formation and accumulation of a mutant huntingtin protein.