中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (11): 2339-2340.doi: 10.4103/NRR.NRR-D-23-01663

• 观点:退行性病与再生 • 上一篇    下一篇

揭示急性间歇性缺氧作为诱导多发性硬化症强有力修复的一种策略的潜力

  

  • 出版日期:2024-11-15 发布日期:2024-03-28

Unraveling the potential of acute intermittent hypoxia as a strategy for inducing robust repair in multiple sclerosis

Valerie M.K. Verge*, Nataliya Tokarska, Justin M. Naniong   

  1. Department of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, SK, Canada (Verge VMK, Tokarska N, Naniong JM) 
    Cameco MS Neuroscience Research Center, University of Saskatchewan, Saskatoon, SK, Canada (Verge VMK, Tokarska N, Naniong JM)
  • Online:2024-11-15 Published:2024-03-28
  • Contact: Valerie M.K. Verge, PhD, valerie.verge@usask.ca.
  • Supported by:
    This work was supported by MS Canada research grants #2362 &# 920666, Canadian Institutes of Health Research (CIHR) grants #142328 & #183666, and University of Saskatchewan College of Medicine CoMRAD grant to VMKV. NT and JMN were supported by University of Saskatchewan College of Graduate and Postdoctoral Studies and College of Medicine Scholarships.

摘要: https://orcid.org/0000-0001-6648-3242 (Valerie M.K. Verge)

Abstract: Multiple sclerosis (MS) is a debilitating inflammatory disease of the central nervous system characterized by immune-mediated segmental demyelination and variable degrees of axonal and neuronal degeneration that contribute to disability. Inducing efficient and effective repair programs following demyelination is a major goal and challenge in MS. Conventional MS therapies focus largely on modulating the immune aspects of the disease contributing to lesions. While this alleviates some symptoms and mitigates damage, it does not tackle the fundamental challenge of effective remyelination, which few MS patients experience, especially in the progressive phase of the disease.