中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (11): 2331-2332.doi: 10.4103/NRR.NRR-D-23-01676

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

在免疫介导的神经病中,神经元运输是功能恢复的关键

  

  • 出版日期:2024-11-15 发布日期:2024-03-28

Neuronal trafficking as a key to functional recovery in immune-mediated neuropathies

Felix Kohle*, Michael Schroeter   

  1. Department of Neurology, University of Cologne and University Hospital Cologne, Cologne, Germany
  • Online:2024-11-15 Published:2024-03-28
  • Contact: Felix Kohle, MD, felix.kohle@uk-koeln.de.
  • Supported by:
    This work was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation): project ID 431549029–SFB 1451 (to MS).

摘要: https://orcid.org/0000-0002-4429-0367 (Felix Kohle)

Abstract: Immune-mediated neuropathies are rare diseases of the peripheral nervous system (PNS), substantially affecting patients’ functionality and quality of life. They are amenable to immunomodulatory treatments, which in many cases stabilize disease progression, but long-term deficits persist in many patients. Such long-term deficits are particularly observed in monophasic autoimmune neuropathies like Guillain-Barré syndrome and also in chronic variants, e.g., chronic inflammatory demyelinating neuropathy (Fadia et al., 2019). In chronic immune neuropathies, we increasingly recognize a slowly progressing degeneration of neurons despite highly active immune therapies – a fact that has been re-discovered in multiple sclerosis, the prototypic central nervous system (CNS) immune disease.