中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (11): 2349-2350.doi: 10.4103/NRR.NRR-D-23-01754

• 观点:退行性病与再生 • 上一篇    下一篇

少突胶质细胞:糖尿病病理生理学中被遗忘的参与者

  

  • 出版日期:2024-11-15 发布日期:2024-03-28

Oligodendroctyes: the forgotten players of diabetes pathophysiology

Juan Antonio López-Villodres, Beatriz García-Díaz*#br#   

  1. Departamento Fisiología Humana, Histología Humana, Anatomía Patológica y Educación Física y Deportiva, Facultad de Medicina, Universidad de Málaga, Málaga, Spain (López-Villodres JA)
    UGC Neurociencia. Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma Bionand), Málaga, Spain (García-Díaz B)
  • Online:2024-11-15 Published:2024-03-28
  • Contact: Beatriz García-Díaz, PhD, beatriz.garcia@ibima.eu.
  • Supported by:
    This work has been funded by Instituto de Salud Carlos III (ISCIII) through the project “CP20-0049” and co-funded by the European Union (to BGD).

摘要: https://orcid.org/0000-0003-2655-571X (Beatriz García-Díaz)

Abstract: Oligodendrocytes (OLs), glial cells that provide myelin sheaths to axons in the central nervous system (CNS), have a dual role. First, this myelin fatty cover around the axons protects the nerves and is crucial for the saltatory propagation of action potentials. Second and not less important, OLs provide trophic support to neurons and axons. Thus, OL metabolism is important for OL well-being and the proper accomplishment of their functions, and OL metabolism energetics directly affect the energy metabolism of neighboring neurons.