中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (12): 2586-2587.doi: 10.4103/NRR.NRR-D-23-01763

• 观点:退行性病与再生 • 上一篇    下一篇

骨髓来源的小胶质细胞为肌萎缩侧索硬化症小鼠模型提供神经保护

  

  • 出版日期:2024-12-15 发布日期:2024-03-30

Bone marrow-derived microglia confer neuroprotection to a mouse model of amyotrophic lateral sclerosis

Beka Solomon*   

  1. Department of Molecular Microbiology and Biotechnology, The Shmunis School of Biomedicine and Cancer Research, the George S. Wise Faculty of Life Sciences Tel-Aviv University, Ramat Aviv, Israel
  • Online:2024-12-15 Published:2024-03-30
  • Contact: Beka Solomon, PhD, beka@tauex.tau.ac.il.

摘要: https://orcid.org/0009-0006-9854-6651 (Beka Solomon)

Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the progressive loss of both upper and lower motor neurons in the brain, brainstem, and spinal cord. The exact mechanisms of ALS are still unclear, but genetic and molecular studies have revealed some key factors that may contribute to motor neuron death. Besides motor neurons, other cell types in the nervous system, such as reactive astrocytes and activated microglia, also show pathological changes and secrete harmful substances and inflammatory cytokines (Appel et al., 2011).