中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (12): 2567-2568.doi: 10.4103/NRR.NRR-D-23-01988

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

成人脊髓胶质祖细胞的异质性和可塑性

  

  • 出版日期:2024-12-15 发布日期:2024-03-30

Glial progenitor heterogeneity and plasticity in the adult spinal cord

Haichao Wei, Jia Qian Wu*   

  1. Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA; Center for Stem Cell and Regenerative Medicine, UT Brown Foundation Institute of Molecular Medicine, Houston, TX, USA; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA
  • Online:2024-12-15 Published:2024-03-30
  • Contact: Jia Qian Wu, PhD, Jiaqian.Wu@uth.tmc.edu.
  • Supported by:
    This work was supported by grants from the NIH, United States (R01AG078728-01 and R21 NS113068), Amy and Edward Knight Fund-the UTHSC Senator Lloyd and B.A. Bentsen Center for Stroke Research (to JQW).

摘要: https://orcid.org/0000-0002-6938-6648 (Jia Qian Wu)

Abstract: Glial progenitor cells were reported to have the capacity to generate various types of cells in both the central nervous system (CNS) and peripheral nervous system. Glial progenitor cells can respond to diverse environmental signals and transform into distinct populations, each serving specific functions. Notably, the adult spinal cord hosts various populations of glial progenitors, a region integral to the central nervous system. During development, glial progenitors express glial fibrillary acidic protein (GFAP; Dimou and Gotz, 2014). However, the specific identities of GFAP-expressing progenitors in the adult spinal cord were not thoroughly investigated. Glial progenitors in the adult spinal cord may hold more heterogeneity and plasticity than previously thought.