中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (12): 2571-2572.doi: 10.4103/NRR.NRR-D-23-02011

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

制瘤素 M:神经炎症中的爱恨交加

  

  • 出版日期:2024-12-15 发布日期:2024-03-30

Oncostatin M: a love-hate relationship in neuroinflammation

Doryssa Hermans, Niels Hellings, Bieke Broux*#br#   

  1. University MS Center, Campus Diepenbeek, Diepenbeek, Belgium (Hermans D, Hellings N, Broux B) 
    Neuro-Immune Connections and Repair Lab, Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium (Hermans D, Hellings N, Broux B)
  • Online:2024-12-15 Published:2024-03-30
  • Contact: Bieke Broux, PhD, bieke.broux@uhasselt.be.
  • Supported by:
    This work was supported by Fonds voor Wetenschappelijk Onderzoek (FWO), Charcot Foundation, Hasselt University (to BB).

摘要: https://orcid.org/0000-0001-8509-2415 (Bieke Broux)

Abstract: Oncostatin M and multiple sclerosis: Every 5 minutes, someone in the world is diagnosed with multiple sclerosis (MS), a chronic inflammatory and degenerative disease of the central nervous system (CNS). MS appears in unpredictable episodes of symptoms, which are highly patient-dependent, but often include visual impairment, muscle weakness/spasms, fatigue, cognitive difficulties, and bladder, bowel, or sexual dysfunction. In severe cases, MS patients become wheelchair-bound due to paralysis. These symptoms are the result of a dysfunctional signal transduction from one neuron to another after the immune system has attacked the neuron’s insulating myelin sheath. Therefore, hyperactivation of immune cells and the presence of demyelinating plaques in the CNS are the main pathological hallmarks of MS.