中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (12): 2557-2558.doi: 10.4103/NRR.NRR-D-23-02015

• 观点:脑损伤修复保护与再生 •    下一篇

抑制微管蛋白脱热:一种促进中枢神经系统再生的新策略

  

  • 出版日期:2024-12-15 发布日期:2024-03-30

Inhibition of tubulin detyrosination: a novel strategy to promote central nervous system regeneration

Charlotte Zeitler, Marco Leibinger, Dietmar Fischer   

  1. Center of Pharmacology, Institute for Pharmacology, Medical Faculty and University of Cologne, Cologne, Germany
  • Online:2024-12-15 Published:2024-03-30
  • Contact: Dietmar Fischer, PhD, dietmar.fischer@uni-koeln.de.

摘要: https://orcid.org/0000-0002-1816-3014 (Dietmar Fischer)

Abstract: The adult mammalian central nervous system (CNS) coordinates essential functions such as sensation, movement, autonomic control, thought processes, and communication. Consequently, injuries or diseases of the CNS are often associated with devastating and permanent functional impairments because damaged axons normally fail to regenerate. An insufficient neuron-intrinsic growth capacity and an inhibitory environment at the injury site are the leading causes of this regenerative failure. Although numerous strategies addressing these issues have enabled considerable axon regeneration in various experimental injury models, clinically applicable treatment options or drugs promoting functional recovery are not yet available.