中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (3): 682-694.doi: 10.4103/NRR.NRR-D-23-02063

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

sirtuin 2在炎症中的上下文依赖性作用

  

  • 出版日期:2025-03-15 发布日期:2024-06-25

Context-dependent role of sirtuin 2 in inflammation

Noemí Sola-Sevilla1, 2, Maider Garmendia-Berges1 , MCarmen Mera-Delgado1 , Elena Puerta1, 2, *   

  1. 1 Department of Pharmaceutical Sciences, Division of Pharmacology, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain; 2 Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
  • Online:2025-03-15 Published:2024-06-25
  • Contact: Elena Puerta, PhD, epuerta@unav.es.
  • Supported by:
    This work was funded by FEDER/Ministerio de Ciencia, Innovación y Universidades Agencia Estatal de Investigación/ Project (PID2020-119729GB-100, REF/AEI/10.13039/501100011033) (to EP); a predoctoral fellowship from the Spanish Ministry of Universities (FPU) and Amigos de la Universidad de Navarra (to NSS); “Programa MRR Investigo 2023” (to MGB and MMD).

摘要: https://orcid.org/0000-0001-5695-5787 (Elena Puerta)

Abstract: Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide (NAD+ )- dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domainleucine-rich-repeat and pyrin domain-containing protein 3 (NLRP3). However, whether sirtuin 2-mediated pathways induce a pro- or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

Key words: interferon, inflammation, lipopolysaccharide, neuroinflammation, NLRP3, nuclear factor κB, sirtuin 2