中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (7): 2005-2007.doi: 10.4103/NRR.NRR-D-24-00442

• 观点:退行性病与再生 • 上一篇    下一篇

衰老和神经退化中的脑内皮 cGAS-STING 信号传导

  

  • 出版日期:2025-07-15 发布日期:2024-11-26

Brain endothelial cyclic GMPAMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway in aging and neurodegeneration

Bryan Sun, Lulin Li, Jian Luo*   

  1. Palo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA, USA (Sun B, Li L, Luo J)  Polytrauma System of Care, VA Palo Alto Health Care System, Palo Alto, CA, USA (Luo J)
  • Online:2025-07-15 Published:2024-11-26
  • Contact: Jian Luo, PhD, jluo@pavir.org.
  • Supported by:
    This work was partially supported by a grant (RF1AG059694) from the U.S. National Institutes of Health and by Polytrauma System of Care, VAPAHCS (to JL

摘要: https://orcid.org/0000-0002-2064-8467 (Jian Luo)

Abstract: The cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway has emerged as a key mediator of neuroinflammation. While current studies primarily attribute its effects to neurons and glial cells, emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature, particularly in brain endothelial cells. Therefore, studying the role of inflammation caused by the cGAS– STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic interventions. Here, we review the multifaceted role of global cGAS–STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS– STING in brain endothelial cells.