中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (12): 3523-3524.doi: 10.4103/NRR.NRR-D-24-00667

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

核酸适配体作为治疗学有前途的新实体:神经系统疾病中得到的经验

  

  • 出版日期:2025-12-15 发布日期:2025-03-15

Aptamers as new promising entities for therapeutics: our experience from the neurological diseases

Macarena Hernández-Jiménez, Fernando de Castro*   

  1. Neurovascular Research Unit, Pharmacology and Toxicology Department, Complutense University, Madrid, Spain (Hernández-Jiménez M) AptaTargets S.L., Avda. Cardenal Herrera Oria, Madrid, Spain (Hernández-Jiménez M)Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain (Hernández-Jiménez M) Instituto Cajal-CSIC, Madrid, Spain (de Castro F)
  • Online:2025-12-15 Published:2025-03-15
  • Contact: Fernando de Castro, MD, PhD, fdecastro@cajal.csic.es.
  • Supported by:
    Macarena Hernández-Jiménez is the scientific advisor of AptaTargets S.L. No conflicts of interest exist between AptaTargets S.L. and publication of this paper. The research group directed by Fernando de Castro developed part of its research from 2018 to 2023 under contracts #20184174 and #Apta_misiones_009 signed with Apta Targets, S.L.

摘要: https://orcid.org/0000-0002-7018-8032 (Fernando de Castro) https://orcid.org/0000-0003-3329-3965 (Macarena Hernández-Jiménez)

Abstract: Based on data from Global Burden of Disease, Injuries, and Risk Factors (2024), disorders of the central nervous system (CNS) are an important cause of death or long-term disability, representing the top-ranked contributor to global disability adjusted life years. This group of pathological conditions includes congenital and neurodevelopmental disorders, cerebrovascular diseases, and neurodegenerative diseases, and induce the disruption of brain growth, brain and/or spinal cord damage, and cognitive, sensory, or motor function impairment. Surprisingly, despite the huge impact of these diseases on the lives of patients, there is a lack of available therapeutic options and the investigation in the field represents real interest in the scientific community nowadays.