中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (11): 3179-3192.doi: 10.4103/NRR.NRR-D-24-00694

• 综述:退行性病与再生 • 上一篇    下一篇

健康和疾病恢复中少突胶质细胞的异质性:对髓鞘病理的深度理解

  

  • 出版日期:2025-11-15 发布日期:2025-02-22

Oligodendroglial heterogeneity in health, disease, and recovery: deeper insights into myelin dynamics

Pieter-Jan Serneels1 , Julie D. De Schutter1 , Lies De Groef2 , Lieve Moons1, *, #, Steven Bergmans1, #   

  1. 1 KU Leuven, Leuven Brain Institute, Department of Biology, Animal Physiology and Neurobiology Division, Neural Circuit Development & Regeneration Research Group, Leuven, Belgium;  2 KU Leuven, Leuven Brain Institute, Department of Biology, Animal Physiology and Neurobiology Division, Cellular Communication & Neurodegeneration Research Group, Leuven, Belgium
  • Online:2025-11-15 Published:2025-02-22
  • Contact: Lieve Moons, PhD, lieve.moons@kuleuven.be.
  • Supported by:
    This work was supported by KU Leuven Internal Funding (C3/21/012) and the Research Foundation Flanders (FWO G092222N) (to LM).

摘要: https://orcid.org/0000-0003-0186-1411 (Lieve Moons)

Abstract: Decades of research asserted that the oligodendroglial lineage comprises two cell types: oligodendrocyte precursor cells and oligodendrocytes. However, recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states, prompting a revision of the existing terminology. Going forward, the oligodendroglial lineage should be delineated into five distinct cell states: oligodendrocyte precursor cells, committed oligodendrocyte precursor cells, newly formed oligodendrocytes, myelin-forming oligodendrocytes, and mature oligodendrocytes. This new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological contexts. Adopting this uniform terminology will facilitate comparison and integration of data across studies. This, including the consolidation of findings from various demyelinating models, is essential to better understand the pathogenesis of demyelinating diseases. Additionally, comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination failure. Thus, by standardizing terminology and synthesizing data from diverse studies across different animal models, we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis, Alzheimer’s disease, and amyotrophic lateral sclerosis, all of which involve oligodendroglial and myelin dysfunction.

Key words: animal models, demyelination, fish, mammals, multiple sclerosis, myelin, neurodegeneration, oligodendrocytes, oligodendroglial lineage, remyelination