中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (10): 2909-2910.doi: 10.4103/NRR.NRR-D-24-00715

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

婴儿脑部瘢痕:新生儿缺氧缺血性脑病模型的免疫学见解

  

  • 出版日期:2025-10-15 发布日期:2025-02-08

Brain scarring in infants: immunological insights from a neonatal hypoxic-ischemic encephalopathy model

Pedro Moreno Pimentel-Coelho*   

  1. Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
  • Online:2025-10-15 Published:2025-02-08
  • Contact: Pedro Moreno Pimentel-Coelho, MD, PhD, pedrompc@biof.ufrj.br.
  • Supported by:
    This work was supported by Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ; E-26/010.002160/2019, E-26/203.227/2017, E-260003/001177/2020, and E-26/201.279/2021), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; 313757/2020-8, 311188/2023-0) (to PMPC).

摘要: https://orcid.org/0000-0002-2414-3386 (Pedro Moreno Pimentel-Coelho)

Abstract: Neonatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of disability in children. Improving brain function and accelerating neurological recovery may require a combination of neuroprotective and pro-regenerative treatments at different stages of HIE. While the first hours after the neonatal insult are the most critical period for neuroprotection, the existence of secondary and tertiary mechanisms of brain injury offers the possibility of preventing delayed neurodegeneration in the subsequent days, weeks, or months (Levison et al., 2022). This extended therapeutic window could also be utilized for therapies aimed at enhancing brain repair and regeneration. In this context, the formation of glial and fibrotic scars, while necessary to maintain or restore the integrity of brain tissue, is considered a major barrier to regeneration and might have delayed detrimental effects on brain function, thus representing a promising target for novel therapies.