中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (2): 671-672.doi: 10.4103/NRR.NRR-D-24-00735

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

倍半萜内酯作为治疗神经损伤的潜在药物

  

  • 出版日期:2026-02-15 发布日期:2025-05-23

Sesquiterpene lactones as potential drugs treating nerve injury

Philipp Gobrecht, Marco Leibinger, Dietmar Fischer*   

  1. Center of Pharmacology, Institute for Pharmacology, Medical Faculty and University of Cologne, Cologne, Germany
  • Online:2026-02-15 Published:2025-05-23
  • Contact: Dietmar Fischer, PhD, dietmar.fischer@uni-koeln.de.
  • Supported by:
    This work was supported by The German Research Foundation.

摘要: https://orcid.org/0000-0002-1816-3014 (Dietmar Fischer)

Abstract: Traumatic axonal lesions of peripheral nerves disrupt neuronal connections with their targets, resulting in the loss of motor and sensory functions. Despite the peripheral nervous system’s capacity for axonal regrowth, this may lead to permanent impairements resulting in a loss of quality of life and a high socioeconomic burden. For example, peripheral nerve injuries in the upper extremities are relatively common, especially due to work-related accidents, and can lead to significant morbidity and long-term costs. A study found that 30% of patients with work-related nerve injuries experienced permanent disabilities, requiring financial compensation and impacting their quality of life. The estimated lifetime cost per patient with severe injury, including treatment, rehabilitation, and compensation, is approximately €102,167, highlighting the substantial economic impact of these injuries (Bergmeister et al., 2020).