中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (12): 3529-3530.doi: 10.4103/NRR.NRR-D-24-00793

• 观点:退行性病与再生 • 上一篇    下一篇

阿尔茨海默病与免疫系统:TEMRA 细胞的新兴作用

  

  • 出版日期:2025-12-15 发布日期:2025-03-15

Alzheimer’s disease and the immune system: the emerging role of TEMRA cells

Edric D. Winford, Adam D. Bachstetter*   

  1. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA (Winford ED) Department of Neuroscience, Sanders-Brown Center on Aging, Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, USA (Bachstetter AD)
  • Online:2025-12-15 Published:2025-03-15
  • Contact: Adam D. Bachstetter, PhD, adam.bachstetter@uky.edu.

摘要: https://orcid.org/0000-0003-4646-6757 (Adam D. Bachstetter)

Abstract: Alzheimer’s disease (AD) is the most common form of dementia, affecting millions worldwide. It is characterized by progressive cognitive decline and changes in behavior and personality, attributed to neuropathological changes, such as amyloid-beta (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau protein. While microglia, the resident immune cells in the brain, are well established as contributors in AD disease progression, recently, T cells in the periphery and the brain have also been highlighted as being important in the progression of AD, with CD8+ T cells reducing amyloid-β pathology and neurodegeneration by interacting with microglia (Su et al., 2023), while increasing tau-mediated neurodegeneration (Chen et al., 2023), showing the possibility of T cells to effect AD neuropathological changes, at least in animal models with specific and isolated AD-related pathologies.