中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (10): 4798-4802.doi: 10.4103/NRR.NRR-D-24-00916

• 综述:退行性病与再生 • 上一篇    下一篇

针对淀粉样β蛋白和Tau的阿尔茨海默病综合治疗前景

  

  • 出版日期:2026-10-15 发布日期:2026-06-12

Prospect in Alzheimer’s disease integrative therapy targeting both amyloid-β and Tau

Wei Zhang1, #, Yiqun Zhou1, 2, #, Jiuyan Chen1, Miranda Perez1, Xiomara Claure1, Roger M. Leblanc1, *   

  1. 1Department of Chemistry, University of Miami, Coral Gables, FL, USA; 
    2C-Dots LLC, Miami, FL, USA
  • Online:2026-10-15 Published:2026-06-12
  • Contact: Roger M. Leblanc, PhD, rml@miami.edu.

摘要: https://orcid.org/0000-0001-8836-8042 (Roger M. Leblanc)
 

Abstract: Alzheimer’s disease is well characterized by the buildup of amyloid-β plaques and tau protein tangles, leading to neurodegeneration and cognitive impairments. Recent prosperous Alzheimer’s disease therapeutic development targeting amyloid-β validates the amyloid hypothesis. Nonetheless, the limited efficacy of single-target therapies plus as-observed synergy between amyloid-β and tau calls for a thorough understanding of Alzheimer’s disease pathogenesis. Thus, this review introduces Alzheimer’s disease pathogenesis, specifically focusing on the amyloid-β and tau pathologies, highlights their interconnected nature, presents personal perspectives on therapeutic and diagnostic challenges, and underscores the necessity of combined therapeutic approaches to effectively address Alzheimer’s disease.

Key words: Alzheimer’s disease, amyloid-β, integrative therapy, interplay, multi-target therapy, tau