中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (12): 3400-3415.doi: 10.4103/NRR.NRR-D-24-00942

• 综述:视神经损伤修复保护与再生 • 上一篇    下一篇

体育锻炼对视网膜神经保护作用的双向因果关系

  

  • 出版日期:2025-12-15 发布日期:2025-03-13

Bidirectional causality of physical exercise in retinal neuroprotection

Stephen K. Agadagba1 , Suk-yu Yau1, 2, *, Ying Liang1 , Kristine Dalton1, 3, Benjamin Thompson1, 3   

  1. 1 Center for Eye and Vision Research Limited, 17W, Hong Kong Science Park, Hong Kong Special Administrative Region, China;  2 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China;  3 School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada
  • Online:2025-12-15 Published:2025-03-13
  • Contact: Suk-yu Yau, PhD, sonata.yau@polyu.edu.hk.
  • Supported by:
    This project was supported by the InnoHK Initiative and the Hong Kong Special Administrative Region Government, China (to SYY).

摘要: https://orcid.org/0000-0002-7425-6741 (Suk-yu Yau) 

Abstract: Physical exercise is recognized as an effective intervention to improve mood, physical performance, and general well-being. It achieves these benefits through cellular and molecular mechanisms that promote the release of neuroprotective factors. Interestingly, reduced levels of physical exercise have been implicated in several central nervous system diseases, including ocular disorders. Emerging evidence has suggested that physical exercise levels are significantly lower in individuals with ocular diseases such as glaucoma, age-related macular degeneration, retinitis pigmentosa, and diabetic retinopathy. Physical exercise may have a neuroprotective effect on the retina. Therefore, the association between reduced physical exercise and ocular diseases may involve a bidirectional causal relationship whereby visual impairment leads to reduced physical exercise and decreased exercise exacerbates the development of ocular disease. In this review, we summarize the evidence linking physical exercise to eye disease and identify potential mediators of physical exercise-induced retinal neuroprotection. Finally, we discuss future directions for preclinical and clinical research in exercise and eye health.

Key words: age-related macular degeneration, biomarkers, diabetic retinopathy, glaucoma, neuroprotective factors, ocular diseases, physical exercise, retinal neuroprotection, retinitis pigmentosa, visual impairment