中国神经再生研究(英文版) ›› 2021, Vol. 21 ›› Issue (5): 1999-2000.doi: 10.4103/NRR.NRR-D-24-01152

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

寄生虫对慢性消耗性疾病传播的潜在影响

  

  • 出版日期:2026-05-15 发布日期:2025-08-22

Potential impact of parasites in the transmission of chronic wasting disease

Paulina Soto, Rodrigo Morales*   

  1. Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX, USA (Soto P, Morales R) Centro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O’Higgins, Santiago, Chile (Soto P, Morales R)
  • Online:2026-05-15 Published:2025-08-22
  • Contact: Rodrigo Morales, PhD, Rodrigo.MoralesLoyola@uth.tmc.edu.
  • Supported by:
    We apologize for the many missing references that should also be quoted. Several review articles have been listed for further reading. This work was supported by a grant from NIH (R01AI132695) to RM.

摘要: https://orcid.org/0000-0001-7766-5770 (Rodrigo Morales)

Abstract: Chronic wasting disease — a prion disease affecting cervids: Many neurological conditions, including Alzheimer’s and Parkinson’s diseases, amyotrophic lateral sclerosis, frontotemporal dementias, among others, are caused by the accumulation of misfolded proteins in the brain. These diseases affect not only humans, but also animals. Prion diseases are a particular group of diseases among neurodegenerative disorders that can manifest in epidemic proportions in livestock and wild animals. These are fatal neurological conditions caused by the misfolding of a physiologically generated protein, termed cellular prion protein or PrPC , to a pathological isoform referred to as PrPSc (Prusiner, 1991). The events leading to the formation of PrPSc are not fully understood at the molecular level; however, these processes are known to occur either stochastically, be favored by mutations in the prion protein gene (PRNP), or templated by exogenous PrPSc particles. Prion diseases have been observed in various mammals, including humans. In all cases, these diseases are characterized by the progressive degeneration of the brain, leading to alterations in behavior, weight loss, and ultimately culminating in death.