中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (3): 1136-1137.doi: 10.4103/NRR.NRR-D-24-01197

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

先天脊髓修复过程中可塑性与再生相适应

  

  • 出版日期:2026-03-15 发布日期:2025-07-04

Plasticity meets regeneration during innate spinal cord repair

Amruta Tendolkar, Mayssa H. Mokalled*   

  1. Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO, USA (Tendolkar A, Mokalled MH) Center of Regenerative Medicine, Washington University School of Medicine, Saint Louis, MO, USA (Mokalled MH) Hope Center for Neurological Disorders, Washington University School of Medicine, Saint Louis, MO, USA (Mokalled MH)
  • Online:2026-03-15 Published:2025-07-04
  • Contact: Mayssa H. Mokalled, PhD, mmokalled@wustl.edu.

摘要: https://orcid.org/0000-0002-3712-351X (Mayssa H. Mokalled)

Abstract: Regenerative capacity of the central nervous system (CNS) is unevenly distributed among vertebrates. While most mammalian species including humans elicit limited repair following CNS injury or disease, highly regenerative vertebrates including urodele amphibians and teleost fish spontaneously reverse CNS damage. Teletost zebrafish (danio rerio) are tropical freshwater fish that proved to be an excellent vertebrate model of successful CNS regeneration. Differential neuronal, glial, and immune injury responses underlie disparate injury outcomes between highly regenerative zebrafish and poorly regenerative mammals. This article describes complications associated with neuronal repair following spinal cord injury (SCI) in poorly regenerative mammals and highlights intersecting modes of plasticity and regeneration in highly regenerative zebrafish (Figures 1 and 2). Comparative approaches evaluating immunoglial SCI responses were recently reviewed elsewhere (Reyes and Mokalled, 2024)