中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (4): 1568-1569.doi: 10.4103/NRR.NRR-D-24-01357

• 观点:退行性病与再生 • 上一篇    下一篇

帕金森病中α-突触核蛋白发病机制的决定因素

  

  • 出版日期:2026-04-15 发布日期:2025-07-27

Determinants of alpha-synuclein pathogenesis in Parkinson’s disease

Oriol Bárcenas, Marc Estivill-Alonso, Salvador Ventura*   

  1. Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Spain (Bárcenas O, Estivill-Alonso M, Ventura S) Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain (Bárcenas O, Estivill-Alonso M, Ventura S) Hospital Universitari Parc Taulí, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain (Bárcenas O, Estivill-Alonso M, Ventura S)
  • Online:2026-04-15 Published:2025-07-27
  • Contact: Salvador Ventura, PhD, Salvador.Ventura@uab.cat.
  • Supported by:
    OB was supported by the Spanish Ministry of Science and Innovation via a doctoral grant [FPU22/03656]. This work was supported by the Spanish Ministry of Science and Innovation (PID2022-137963OB-I00), Generalitat de Catalunya (2021-SGR-00635 AGAUR), CERCA Programme (Generalitat de Catalunya) and by ICREA, ICREA-Academia 2020 (to SV). Helical peptides targeting α-syn are protected by U.S. Patent Application No. 18/005,998 in which SV is an inventor.

摘要: https://orcid.org/0000-0002-9652-6351 (Salvador Ventura)

Abstract: Alpha-synuclein and Parkinson’s disease: Neuronal damage and inflammation caused by the aggregation of alpha-synuclein (α-syn) are central to a group of disorders known as synucleopathies, which includes Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy, among others. PD, the most common synucleinopathy, is the second most prevalent neurodegenerative disease after Alzheimer’s disease, and it is the fastest growing. Its primary hallmark is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, disrupting the communication with the striatum. This has adverse motor and nonmotor effects, with the most prominent symptoms being tremors, rigidity, instability, and gait difficulties. While most patients have a late onset (60+ years), certain dominant genetic mutations in the gene encoding α-syn are associated with earlier onset. Despite the severity and prevalence of the disease, no treatments that halt or modify the pathology progression exist, with available therapies providing only symptomatic relief for motor symptoms (Vázquez-Vélez and Zoghbi, 2021).