中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (3): 1110-1111.doi: 10.4103/NRR.NRR-D-24-01414

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

细胞Phf8调控:少突胶质细胞发育过程中的表观遗传调控

  

  • 出版日期:2026-03-15 发布日期:2025-07-04

Cell Phf8 [ˈfeɪt] control: Epigenetic regulation during oligodendroglial development

Marco Kremp, Michael Wegner*   

  1. Institut für Biochemie, Friedrich-AlexanderUniversität Erlangen-Nürnberg, Erlangen, Germany
  • Online:2026-03-15 Published:2025-07-04
  • Contact: Michael Wegner, PhD, michael.wegner@fau.de.
  • Supported by:
    This work was supported by grants from the Deutsche Forschungsgemeinschaft (DFG) to MW.

摘要: https://orcid.org/0000-0003-4174-2644 (Marco Kremp) https://orcid.org/0000-0002-4586-3294 (Michael Wegner)

Abstract: Oligodendrocytes and their cell-intrinsic gene regulatory network: Oligodendrocytes (OLs) are the myelinating glial cells of the vertebrate central nervous system. They are responsible for insulating neuronal axons with a lipid-rich myelin sheath, which enables the saltatory conduction of action potentials. During development, oligodendrocyte progenitor cells (OPCs) emerge from neural stem cells in the ventricular zone. They then proliferate, increase their number, and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes (mOLs) under the influence of environmental stimuli.