中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (3): 1104-1105.doi: 10.4103/NRR.NRR-D-24-01465

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

溶血磷脂酸信号:中枢神经系统的跨膜调节剂

  

  • 出版日期:2026-03-15 发布日期:2025-07-04

Lysophosphatidic acid signaling: Transmembrane modulators in the central nervous system

Alexandra Polyzou* , Alexandros Κ. Tsiouris, Charalampos Labrakakis, Britta J. Eickholt, George Leondaritis*   

  1. Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece (Polyzou A, Tsiouris AK, Leondaritis G) Department of Biological Applications and Technology, School of Health Sciences, University of Ioannina, Ioannina, Greece (Labrakakis C) Institute of Biosciences, University Research Center of Ioannina (URCI), Ioannina, Greece (Labrakakis C, Leondaritis G) Institute for Molecular Biology and Biochemistry, Charité Universitätsmedizin Berlin, Berlin, Germany (Eickholt BJ)
  • Online:2026-03-15 Published:2025-07-04
  • Contact: Alexandra Polyzou, PhD, alexandrapolyzou@gmail.com; George Leondaritis, PhD, gleondar@uoi.gr.
  • Supported by:
    This work was supported by the Hellenic Foundation for Research and Innovation, HFRI, “2nd Call for HFRI Research Projects to support Faculty Members & Researchers” Project 02667 to GL.

摘要: https://orcid.org/0009-0003-9221-8276 (Alexandra Polyzou) https://orcid.org/0000-0001-8385-8341 (George Leondaritis)

Abstract: Lysophosphatidic acid (LPA) is a pleiotropic lipid agonist essential for functions of the central nervous system (CNS). It is abundant in the developing and adult brain while its concentration in biological fluids, including cerebrospinal fluid, varies significantly (Figure 1Α; Yung et al., 2014). LPA actually corresponds to a variety of lipid species that include different stereoisomers with either saturated or unsaturated fatty acids bearing likely differentiated biological activities (Figure 1Α; Yung et al., 2014; Hernández-Araiza et al., 2018). During CNS development, LPA influences critical processes such as cell proliferation, survival, and differentiation, promotes neuronal migration, and affects neuronal morphology (Yung et al., 2014). Furthermore, LPA mediates cortical development, myelination, pain, synaptic transmission, and plasticity (Yung et al., 2014). Deregulation of LPA signaling contributes to a myriad of CNS pathologies including psychiatric diseases, neurodegeneration, neuropathic pain, neuroinflammatory, and traumatic conditions (Yung et al., 2014).