中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (3): 1106-1107.doi: 10.4103/NRR.NRR-D-24-01559

• 观点:退行性病与再生 • 上一篇    下一篇

无机多聚磷酸盐能否成为抗神经元衰老的有效靶点?

  

  • 出版日期:2026-03-15 发布日期:2025-07-04

Could inorganic polyphosphate be a valid target against neuronal senescence?

Luca Tagliafico, Maria E. Solesio*   

  1. Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa, Italy (Tagliafico L) IRCCS Ospedale Policlinico San Martino, Genoa, Italy (Tagliafico L) Department of Biology and Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA (Tagliafico L, Solesio ME)
  • Online:2026-03-15 Published:2025-07-04
  • Contact: Maria E. Solesio, PhD, m.solesio@rutgers.edu.
  • Supported by:
    We thank Mitch Maleki, Esq., for editing this manuscript.We apologize to colleagues whose work has not been cited due to the strict restrictions on the number of citations that are permitted by the editors of the journal for perspective articles.

摘要: https://orcid.org/0000-0002-8105-1701 (Maria E. Solesio)

Abstract: Aging is considered the main risk factor for the development of several diseases, including the leading neurodegenerative disorders. While the cellular features of aging are complex and multifaceted, neuronal senescence has emerged as a major contributor and driver of this process in the mammalian cell. Cellular senescence is a programmed response to stress and irreparable damage, which drives the cell into an apoptosisresistant, non-proliferative state. Senescent cells can also deleteriously affect neighboring, nonsenescent cells. Senescence is a complex and multifaceted process associated with a wide range of cellular events, including the secretion of proinflammatory molecules and the arrest of the cell cycle. Additionally, mitochondrial dysfunction has been broadly demonstrated in senescent cells (Lopez-Otin et al., 2013). Despite their postmitotic nature, albeit with some controversy, it is now widely accepted that neurons can also display senescence.