中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (6): 2409-2410.doi: 10.4103/NRR.NRR-D-24-01628

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

改善创伤性脊髓损伤的恢复:针对髓鞘再生与白质重塑

  

  • 出版日期:2026-06-15 发布日期:2025-09-18

Improving recovery from traumatic spinal cord injury: Targeting remyelination versus white matter remodeling

Bethany R. Kondiles* , Wolfram Tetzlaff   

  1. International Collaboration on Repair Discoveries, Department of Zoology, University of British Columbia, Vancouver, BC, Canada
  • Online:2026-06-15 Published:2025-09-18
  • Contact: Bethany R. Kondiles, PhD, kondiles@icord.org.
  • Supported by:
    We thank Dr. Greg J. Duncan for (Oregon Health & Science University, USA) the use of his data and his valuable feedback on this manuscript. Figure 1 was created in BioRender. Tetzlaff, W. (2025) https://BioRender.com/ d06y619; https://BioRender.com/h19t597. This work was supported by Grant 3195 from Paralyzed Veterans of America Research Foundation (to BRK). WT holds the Edie Ehlers Chair in spinal cord injury.

摘要: https://orcid.org/0000-0002-9297-8529 (Bethany R. Kondiles) https://orcid.org/0000-0003-3462-1676 (Wolfram Tetzlaff)

Abstract: The inter-related pathological cascades following a traumatic spinal cord injury (tSCI) disrupt multiple cell types and physiological processes. Subsequently, motor and sensory functions are disrupted by breakdowns in cellular interactions and circuitry. Therapeutic interventions seek to modify some aspects of the injury course to enable the re-establishment of functional circuitry. Interventions often target one cell type (e.g., promoting neuroprotection or neural regeneration) or one process (e.g., modulating inflammation, affecting astrocytic, microglial, or macrophage responses.) Many axons in the spinal cord are myelinated, and after injury oligodendrocyte death causes demyelination. Promoting remyelination of spared or new axons to re-establish conduction seems a logical choice as a therapeutic target. However, “remyelination” refers to a binary process: the presence or absence of myelin regeneration. “White matter remodeling” considers the plasticity of and interactions between the multiple cell types essential for signal conduction. As the field develops more combinatorial approaches, wherein interventions target multiple cell types and processes, incorporating the concept of white matter remodeling, as opposed to remyelination, considers how to re-establish the requisite cellular circuitry necessary for regaining function.