中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (8): 3426-3438.doi: 10.4103/NRR.NRR-D-25-00439

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

Foxg1及其同伴:不仅仅是转录因子

  

  • 出版日期:2026-08-18 发布日期:2026-04-25

Foxg1 and companions: Not only transcription factors

Antonello Mallamaci1, *, Osvaldo Artimagnella2, #, Gabriele Liuzzi1, #   

  1. 1Laboratory of Cerebral Cortex Development, SISSA, Trieste, Italy; 
    2IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy
  • Online:2026-08-18 Published:2026-04-25
  • Contact: Antonello Mallamaci, PhD, amallama@sissa.it.
  • Supported by:
    This work was supported by SISSA (intramural funding to AM), International FOXG1 Research Foundation (Grant to AM), Italian Ministery of University and Research (Grant PRIN22 2022M95RC7 to AM), and Fondazione Telethon (Grant GMR22T2018 to AM).

摘要: https://orcid.org/0000-0002-3621-1307 (Antonello Mallamaci)

Abstract: Moving from the most recent results on Foxg1 biology, we first summarize the available information on some special pleiotropic effectors of neurodevelopmental interest, involved in controlling both transcription and posttranscriptional steps of gene expression. Then, after further analysis of the literature, we report evidence that, not strictly limited to neurodevelopmental effectors, such pleiotropy also applies to other transcription factors, involved in physiology and homeostasis. Furthermore, through the systematic analysis of a major public protein–protein interaction database, we gather strong evidence that the involvement of “canonical” transcription factors in posttranscriptional control of gene expression could be a pervasive phenomenon, characterizing hundreds of effectors. Finally, we discuss the biological significance of these findings and propose three evolutionary mechanisms that may have contributed to such an unexpected scenario.

Key words: BioGrid, co-transcriptional transfer, genetic pleiotropy, neuronal plasticity, polyadenylation, protein biosynthesis, splicing, transcription factors, triplosensitivity