中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (8): 3535-3536.doi: 10.4103/NRR.NRR-D-25-00532

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓损伤中的性别特异性适应性免疫反应:跨物种观察

  

  • 出版日期:2026-08-18 发布日期:2026-04-25

Sex-specific adaptive immune responses in spinal cord injury: observations across species

Reena Kumari, John C. Gensel*   

  1. Spinal Cord and Brain Injury Research Center, Department of Physiology, University of Kentucky College of Medicine, Lexington, KY, USA
  • Online:2026-08-18 Published:2026-04-25
  • Contact: John C. Gensel, PhD, gensel.1@uky.edu.
  • Supported by:
    This work was supported by University of Kentucky-SCoBIRC Endowed Chair #5; Craig H. Neilsen 1173493 and NIH RF1NS135504 (to JCG)

摘要: https://orcid.org/0000-0001-8980-108X (John C. Gensel)

Abstract: Biological sex is increasingly recognized as a crucial factor in evaluating the translational value of preclinical spinal cord injury (SCI) studies. The rising incidence of SCI in females challenges the historical precedent of SCI being a maledominated condition. In contrast, most basic science researchers utilize single-sex studies to minimize complications associated with bladder care in males (Stewart et al., 2020). The findings of our recent publication identify sexually dimorphic immune responses to SCI in both mice and pigs (Kumari et al., 2025). Here, we will highlight these findings and discuss the impact of sex on SCI inflammation and recovery.