中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (9): 3983-3990.doi: 10.4103/NRR.NRR-D-25-00806

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

大麻素受体在组织和细胞水平上表达的物种差异

  

  • 出版日期:2026-09-15 发布日期:2026-05-15

Interspecies differences in the expression of cannabinoid receptors at the tissue and cellular level

Sydney Lawley, Audrey Green, Cole Johnson, Michael D. Burton*   

  1. Neuroimmunology and Behavior Lab (NIB), Department of Neuroscience, School of Behavioral and Brain Science, Center for Advanced Pain Studies (CAPS), University of Texas at Dallas, Richardson, TX, USA
  • Online:2026-09-15 Published:2026-05-15
  • Contact: Michael D. Burton, PhD, michael.burton@utdallas.edu.
  • Supported by:
    This work was supported by the NIH/NIDDK grants: R35GM147094 (to MDB), R21DK130015 (to MDB), the University of Texas System STARS program research support grant (to MDB), and the Rita Allen Foundation Grant (to MDB). SL was supported by the Enhancing Neuroscience Undergraduate Research Experience Program funded by the Communities Foundation of Texas and NIH/NIGMS grant: T34GM14543.

摘要: https://orcid.org/0000-0002-0628-824X (Michael D. Burton)

Abstract: Understanding the cellular and molecular distribution of cannabinoids can address a highly contentious perspective in the pain neuroscience field: whether cannabinoids are viable in pain relief. Due to insufficient evidence for cannabinoids in reducing pain in clinical trials and gaps in knowledge across the translational research process, the International Association for the Study of Pain (IASP) published a position statement in 2021 recommending against the general use of cannabinoids to treat pain. A possible mechanistic reason for the lack of translatability is interspecies differences in the expression of the cannabinoid type 1 and type 2 receptors at the tissue and cellular levels. Additionally, the anatomical site that is most important for analgesia has been elusive. This review aims to provide a deeper understanding of the anatomical distribution of cannabinoid receptors throughout the nervous system across species. We traverse historical and contemporary literature to illustrate the progression of methodology and perspectives. We discuss co-localized markers on cannabinoid receptor-expressing cells to elucidate possible anatomically dependent roles of the endocannabinoid system. We also discuss differences in cannabinoid receptor expression across species that may contribute to challenges in translatability between rodents and humans. Lastly, we cover how various types of pain can differentially alter the expression of cannabinoid receptors and how this may impact cannabinoid-based therapeutics.

Key words: CB1R, CB2R, endocannabinoid system, human, mouse, rat, rodent, species differences, translational research